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2 and described in detail in the “Ca 2+ signaling,” “ROS signaling,” “Ceramide signaling,” “Eryptosis and caspases,” “Crosstalk between eryptosis and necroptosis in erythrocytes: Is caspase-8 involved?,” “Eryptosis-associated kinases,” “Extrinsic Fas-mediated eryptosis,” “Nitric oxide signaling,” “GTPase signaling,” and “Cellular energy metabolism and eryptosis” sections Ca 2+ signaling Ca 2+ plays an important role in apoptosis signaling of nucleated cells [96]